Infertility is a prevalent health issue that affects millions of couples worldwide, with male infertility rates steadily increasing. Abnormal spermatogenesis and spermiogenesis are major contributors to male infertility. Various risk factors, including socio-demographic, environmental, behavioral/lifestyle, genetic factors, etc., play an intertwined role in the onset of male infertility. Although assisted reproductive technologies (ART) offer hope, their limited accessibility and affordability discourage couples from seeking infertility treatment. Semen analysis is a vital laboratory test that measures various physical and microscopic parameters to assess semen quality. This study aimed to evaluate the impact of multiple factors, including age, BMI (Body Mass Index), and lifestyle, on semen quality associated with male infertility. The findings of this study highlight the importance of a comprehensive approach to diagnosing male infertility. Furthermore, this approach advances our understanding of the association between the aetiology and pathophysiology of male infertility, offering insights for developing prevention and treatment strategies.