Uncontrolled hyperglycaemia gives raise to dysfunctions of the liver and kidney among other complications. Regulating the levels of sugar with available conventional substances often produce undesirable effects, therefore, search from medicinal plants for alternative anti-diabetic treatment cannot be overburdening. The study was undertaken to explore the potential(s) of Phyllanthus fraternus methanolic leaf extract in ameliorating kidney and liver dysfunctions in diabetic rats.