Th e aim of the present is to investigate the therapeutic capabilities of gramine in treating liver diseases by utilizing Insilco molecular docking technique and evaluating ADMET (absorption, distribution, metabolism, elimination and toxicity) parameters also. The study further assesses the binding effectiveness through docking studies against 10 target proteins (TNF α, IL6, PIK3, GSK3B, LPL, PPARG, AKTI, PPAR A, MAPK 8 and NF κβ1) associated with liver diseases. Ursodeoxycholic acid, silymarin and L Ornithine L Aspartate served as reference drugs . Notably gramine exhibited good binding affinity for PIK3, GSK3B, PPARA, PPARG, AKTI, MAPK8, TNFα, LPL, IL 6 The binding affinity was high for silymarin, ursodeoxycholic followed by gramine and L o rnithine L aspartate . Gramine also show sgood intestinal absorption rate, plasma protein binding as well as non carcinogenic in nature . However, further validating all the results in vitro and in vivo would be the best way to characterize the property of gramine as therapeutic liver drug.