proteomics has emerged as a highly promising and innovative field within dentistry, offering a wide range of possibilities for non-invasive and convenient diagnostics, monitoring, and prediction of oral health conditions. By analyzing proteins present in saliva and utilizing advanced high throughput proteomic techniques, researchers have unlocked new avenues for identifying potential biomarkers linked to various oral diseases. Consequently, the application of salivary proteomics has the capacity to bring about a revolutionary transformation in the field of dentistry, providing invaluable insights into the pathogenesis, early detection, and personalized treatment of oral diseases. This comprehensive review aims to explore the multifaceted applications and recent advancements of salivary proteomics in various aspects of dentistry, shedding light on both its potential and limitations. By conducting a thorough evaluation of the current state of salivary proteomics in dentistry, this review seeks to underscore its significance and the opportunities it presents for enhancing oral healthcare. The review will delve into how proteomic techniques have enabled the identification of specific protein signatures that could serve as indicators for various oral health conditions, including periodontal diseases, dental caries, and even oral cancers. Through the identification of salivary biomarkers, dental professionals can not only achieve more accurate disease diagnoses but also predict disease progression and treatment responses more effectively, thereby enabling personalized healthcare approaches for individual patients. In conclusion, salivary proteomics holds immense promise in transforming the landscape of dentistry. Its non-invasive nature, combined with its potential to offer valuable insights in to oral health conditions, makes it an exciting area of research. This comprehensive review aims to provide a detailed overview of the current state of salivary proteomics in dentistry, discussing its applications, challenges, and future prospects.