ISSN : 2663-2187

Formulation and Characterization of Phospholipid Complex of OugeniaOojeinensis Extract

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Dhananjay Rai, Vishal Soni
» doi: 10.48047/AFJBS.6.Si3.2024.2751-2761

Abstract

Background: Ougeniaoojeinensis, a medicinal plant, faces challenges in therapeutic application due to poor bioavailability of its active compounds. This study aimed to enhance bioavailability through the formulation of a phospholipid complex, thereby improving drug delivery efficiency. Objectives: Formulate and characterize a phospholipid complex of Ougeniaoojeinensis extract, evaluate its physicochemical properties, stability under varying conditions, and assess in vitro release kinetics. Materials and Methods: Ougeniaoojeinensis extract was obtained via hydroalcoholic extraction. The phospholipid complex was prepared using the solvent evaporation method with soya phosphatidylcholine. Characterization included dynamic light scattering (DLS) for particle size (180 nm) and zeta potential (-30 mV), FTIR spectroscopy for molecular interactions, DSC for thermal behavior, and XRD for crystallinity. Stability was assessed over three months at different temperatures, revealing minimal changes in particle size and encapsulation efficiency at refrigerated conditions and mild aggregation at 40°C. In vitro release studies, conducted in PBS at 37°C, demonstrated sustained release kinetics with 90% cumulative release over 24 hours. Results: The phospholipid complex exhibited stable physicochemical properties suitable for drug delivery applications. FTIR confirmed interactions between extract and phospholipid, while DSC indicated complex formation with reduced crystallinity observed via XRD. Stability studies supported the complex's robustness under refrigerated storage, with acceptable performance at elevated temperatures. In vitro release profiles indicated controlled and sustained release of active constituents, enhancing bioavailability. Discussion and Summary: Phospholipid complex formulation of Ougeniaoojeinensis extract shows promise in overcoming bioavailability limitations associated with traditional formulations. Further optimization and pharmacokinetic studies could validate its potential for therapeutic applications, offering a novel approach to herbal medicine delivery.

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