The present work was designed to develop pulsatile drug delivery system of Rabeprazole sodium. The Rabeprazole sodium degraded in acidic media of stomach and hence, reduced bioavailability. So, the core tablet containing drug and other excipients were press coated and enteric coated to protect and delay the drug release before the time as per the need of Chronomodulateddrugdeliverysystem.Presscoatingwasperformedwithdifferentgradesof HPMC and EC and ratios. The press coated tablets were optimized by the drug release study and finally 7:1 ratio of EC and HPMC K-4M was selected as optimized ratio. This press coated tablet was further enteric coated with Cellulose acetate phthalate (CAP) using PEG- 400 as plasticizer and acetone as solvent. The weight gain of enteric coating was optimized based on integrity of coating in acidic solution for about 2 hours. The 10 % weight gain was finally selected.Theoptimized formulation F21 showed drugreleasefrom 270 minutes,with rupturetime120minutes,hardness5.23±0.25kg/cm2andaveragediameterof10.2±0.10mm. It revealed 95.4% drug release in about 7 hours. The optimized formulation was passed in weight variation as per Indian Pharmacopoeia.