ISSN : 2663-2187

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF POORLY WATER SOLUBLE DRUG LOPERAMIDE HCL

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Afreen Nagori*, Dr. Vikas Jain*, Dr. S.C. Mahajan*
ยป doi: 10.33472/AFJBS.6.5.2024. 4565-4574

Abstract

The fast-dissolving tablet (FDT) is an innovative and unique drug delivery system that is rapidly gaining attention in fast-dissolving technology research. Fast dissolving tablets are proving to be one of the most popular and widely accepted dosage forms, especially in pediatric patients due to incomplete development of muscles and nervous system and in geriatric patients suffering from Parkinson's disease or hand tremors. The oral dosage form and route is the most preferred route of administration for various drugs that have limitations such as e.g. First-pass metabolism, psychiatric patients, disabled and uncooperative patients. FDTs break down or quickly dissolve in saliva without the need for water. The FDTs formulation contains Superdisintegrants to increase the rate of dissolution of a tablet in the oral cavity. FDT have advantages such as easy portability and formulation, accurate dosage, good chemical and physical stability, and is an ideal choice for geriatric and pediatric patients. FDTs are rapidly degraded, rapidly absorbed and therefore improve the release time of the drug in vitro and this property of the drug (dosage form) increases bioavailability. This review article covers different FDT techniques, criteria of FDT, advantages and disadvantages of FDT, selection of superdisintegrants, different patented technologies, challenges faced FDT, evaluation parameters of FDT, marketed preparation of FDT.

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