Objective: The objective of this study was to create and analyze graphene-based nanocrystals (GNCs) for the purpose of delivering drugs topically. The main focus was on improving the capacity of usnic acid to dissolve, remain stable, and be absorbed by the body. Materials and Methods: Graphene oxide (GO) was synthesized and subsequently reduced to rGO. Afterwards, it was functionalized with Polythene Glycol (PEG). The process of incorporating usnic acid into the GNCs involved using sonication and pH modification to create stable formulations. The characterization process included the use of SEM to examine the morphology, FTIR to analyze chemical interactions, and zeta sizer to determine particle size. Additionally, an assessment was conducted on physicochemical characteristics including pH, viscosity, and spreadability. Results: The nanoscale morphology of several formulations was confirmed by SEM examination, revealing an average particle size range of 500-900 nm. The FTIR spectra demonstrated the effective integration of usnic acid without any chemical modification. The formulations demonstrated consistent pH levels within the range of 6.3-6.4, appropriate viscosity, and effective spreadability. Conclusion: The study showcases the ability of graphene-based nanocrystals to significantly improve the pharmacological characteristics of usnic acid, presenting a hopeful strategy for topical drug delivery systems. The results emphasize the capability of GNCs to surpass skin barriers and enhance the effectiveness of treatments in dermatology.