Merely exhibiting pH-dependent solubility, lornoxicam is a non-steroid anti-inflammatory drug that is just 18 μg mL−1 soluble in water (pH 7.0). Its numerous disadvantages include low solubility, irritation in the gastrointestinal system, and decreased absorption when taken orally. Methods: To address the low aqueous solubility, dissolution, and stability issues related to lornoxicam, the primary goal of this research is to prepare a lornoxicam nanosuspension using the High pressure homogenization method with Poloxamer 188, increase its efficiency, and use spray drying techniques to turn the liquid nanosuspension into a solid form. Results: The physical properties of lornoxicam and the produced nanosuspension were assessed using infrared spectroscopy, powder X-ray diffraction, and differential scanning colorimetry. Conclusions: Measurements of physicochemical parameters such as solubility and dissolution rate revealed that Lornoxicam Nanosuspension dissolved more quickly than the original drug.