The purpose of this research was to formulate and evaluate of microparticulate drug delivery of Rivastigmine for effective treatment of Alzheimer’s disease. Rivastigmine microspheres were prepared by non-aqueous solvent evaporation technique using Ethyl cellulose, Eudragit S 100 and Eudragit RS 100 as polymers. Results of preliminary trials indicate that volume of different solvents used, time taken for preparation of microspheres, polymer-to-drug ratio, and speed of rotation affected characteristics of microspheres. Prepared microspheres were discrete, spherical, and free flowing. The microspheres exhibited high percentage drug entrapment efficiency and yield. The drug release was also sustained for more than 10 hours. So from the above study, it can be concluded that Rivastigmine loaded microspheres can serve as an effective tool for the treatment of Alzheimer’s disease.