Due to its remarkable performance in all measured parameters and compliance with all stipulated requirements, batch F4 was determined to be the best formulation. The results show that enteric-coated omeprazole nanoparticle tablets have a promising future as a controlled release medication for the treatment of duodenal ulcers. Omeprazole's capacity to improve treatment results for patients with duodenal ulcers is demonstrated by both its efficient and controlled release in the intestines and its effective protection in the stomach. This study offers a potential strategy for enhancing the effectiveness and safety of oral drugs and opens the door for additional research and development in the area of nanoparticle-based drug delivery systems.