At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration. Nifedipine (NF) is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. NF is a selective calcium-channel blocker and a peripheral arterial vasodilator which acts directly on vascular smooth muscle. The present research was based on the Formulation and evaluation of transdermal patch of Nifedipine. Preformulation studies was performed for the drug Nifedipine. After it was identified for appearance, solubility, melting point etc. and drug-excipients compatibility study. Preparation of transdermal patches using different polymers and their combinations was done. The developed transdermal patches were evaluated for the weight uniformity, thickness, tensile strength, folding endurance, swelling index, water vapour transmission, percentage moisture content and flatness. In results, Formulation EF1 to EF4 were designed by taking combination of EC and Eudragit S-100 as film forming polymer along with PEG-400 as plasticizer and DMSO as permeation enhancer. All the formulation were easily peeled off and had smooth surface, uniform texture and transparent. The all films were evaluated and results were reported. Based on film characteristics Ethyl cellulose and Eudragit S-100 film were selected. The ex- vivo permeation was studied which revealed that formulation EF2, EF3 and EF4 showed 33.2±0.20%, 35.4±0.24% and 40.1±0.25% drug release respectively. The formulation EF4 was selected as finally optimized formulation as it showed 40.1±0.25% drug release. Further it followed zero order kinetics and can be used as once a day transdermal patch. In conclusion, we optimize the ratio and weight of polymer required to achieve proper thickness, elegance and other transdermal patch characteristics for Nifedipine transdermal patch.