The main objective of this work was to create and analyses nanoparticles of Itraconazole using solvent displacement or nano precipitation methods. The Preformulation research assessed the organoleptic characteristics, solubility, melting point, partition coefficient, and identification using FT-IR spectroscopy and UV spectroscopy. Itraconazole exhibited the properties of a finely textured, odorless, and white to yellow powder. It shown limited solubility in aqueous solvents, but significant solubility in alcohol and methylene glycol. The melting point of the substance was confirmed to be 162.2°C, consistent with the values documented in the literature. The purity of the drug powder was confirmed using FT-IR spectroscopy, while a calibration curve for quantification was constructed by UV spectroscopy. Subsequently, Itraconazole nanoparticles were synthesized and characterised for their drug content, zeta potential, polydispersity index (PDI), and particle size. The formulations displayed particle sizes appropriate for transdermal administration, with entrapment efficiencies often above 62% and particle sizes ranging from 194 to 584 nm. Further research focused on the fabrication of transdermal patches containing Itraconazole nanoparticles. The drug concentration, thickness, tensile strength, folding durability, moisture absorption, and in vitro drug release kinetics were assessed. The polymer ratios used in the development were altered. The findings suggest that these formulations have the capacity to be used in transdermal treatments for regulated and prolonged drug administration purposes.