ISSN : 2663-2187

FORMULATION AND IN-IVTRO EVALUATION OF SOLUBILITY ENHANCEMENT OF AZILSARTAN MEDOXOMIL USING NANO SUSPENSION TECHNOLOGY

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Pasam Jyothirmayi, Abbineni Anusha, Dr. N. Srinivasa Rao
» doi: 10.33472/AFJBS.6.9.2024.1388-1402

Abstract

Poor aqueous solubility of some drug molecules is a major problem in drug formulation. Drug nano suspensions emerged as one solution to delivering such hydrophobic drugs. Scaling down to nano suspensions enhances drug aqueous solubility and bioavailability by increasing drug surface area that comes into contact with biological media. Azilsartan's oral nanosuspension was prepared using Solvent evaporation technique using different polymers like SLS, PVP-K30, poloxamer 188. For trapment efficiency, zeta potential, SEM analysis, invitro dissolution research, all the formulation was assessed. It was discovered that all the prepared formulations had trap effectiveness within acceptable boundaries of 86.36±0.54%- 96.54±0.52% respectively. Studies of IR spectroscopy showed no drug-exceptional interactions. Compared to other formulations, all F3 formulations are the finest formulations, showing 98.40 percent of the drug produced in 45 minutes respectively and following the kinetics of first order release

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