The goal of this work was to create Oseltamivir (Osm) microspheres through the combination of various polymers, including xanthan gum (XG), sodium alginate (SA), and karaya gum (KG). The ionotropic gelation process was used for producing the Osm microspheres. Oseltamivir acts as sialidase inhibitor with antiviral qualities . Osv prevents the virus's surface-resident enzyme, viral neuraminidase, from executing its task. Thirteen formulations of Oseltamivir microspheres were prepared. OS11 was found to be a target formulation among them. Pre-formulation tests and evaluation characteristics like yield (%), drug content (%), particle size, buoyancy, entrapment (%) efficiency, surface morphology, and dissolution studies were assessed for each formulation. Kinetic models were fitted with the results. FM11 microspheres were spherical in form and stiff. Osv was properly dispersed throughout the microspheres. After taking into account all the factors, such as the particle size (439.92±0.47µm to 636.8±0.91µm), yield (%) (73.24±0.81 to 89.27±2.18%), buoyancy (%) (81.09±0.46 to 97.89±0.08 %), entrapment (%) efficiency (93.28±0.27 to 98.69±0.38%), and other factors, FM11 was identified as the target formulation. This formulation was developed by SA:KG:XG in a ratio of 1:1.5:1.5, and the release showed zero-order with an anomalous transport behavior.