Diabetes mellitus is a metabolic disorder with multiple complications. Hypertension is common ailment in diabetic patient.The present research is concerned with the development of buccal tablet formulation by using Pioglitazone and Cilnidipine with an attempt toenhance the bioavailability by reducing the first pass metabolism. The buccal tablets were prepared by using carbopol 974, HPMC K15 cps, Sodium CMC, PEG, lactose, magnesium stearate, ethyl cellulose, in varying concentration by direct compression method. The prepared buccal tablets were evaluated for organoleptic properties, hardness, friability, drug content, surface pH, bioadhesion strength, ex-vivo residence time, swelling index which were found to comply with pharmacopoeial requirements. In-vitro drug release studies were carried out. Stability study indicates that buccal tablets are stable with respect to drug content and dissolution and optimized formulation has good stability in human saliva. mucoadhesive strength of tablets were found to be in the range 4.00 to 8.00 gm which is within standard limit.Experimental result showed that force of adhesion increased in ascending order of increase in polymer concentration. The surface pH of the tablets was in the range of 6.6 to 6.9 which are safe to buccal mucosa. The dissolution results were found to be in the range of 95.36 and 99.00%. These formulations showed good bio adhesion strength. It was inferred that the prepared buccal tabletswill have promising utilities in management of diabetic patient with hypertension.