Optimizing medication administration to achieve maximum therapeutic effectiveness while minimizing adverse effects is pivotal for desired outcomes. This study delves into the development of a viable dosage form through a comprehensive exploration of physicochemical mechanisms governing a specific medication. Orally dissolving tablets (ODTs) have emerged as a promising option, especially for individuals facing difficulties swallowing conventional pills due to dysphagia, a condition prevalent among various age groups, notably the elderly and those with neurological disorders. ODTs offer advantages by dissolving in saliva without the need for water, enhancing accessibility for diverse patient populations. They have been studied extensively for their potential to modify drug-dissolving profiles, enhance bioavailability, and improve patient compliance, particularly by masking the unpleasant taste of active compounds. Numerous techniques, including lyophilization, molding, freeze-drying, and direct compression, have been utilized to develop commercially available ODTs. Recent advancements such as the WOW tab technology, flash tab technique, and orosoly procedures showcase innovative approaches protected by patents. In this investigation, Alverine orodispersible tablets were formulated using specific disintegrants and the direct compression method, yielding nine formulations meeting acceptable pre-compression parameters. Compatibility studies confirmed the integrity of Alverine without any drug-excipient interactions. Among the formulations, P4 and P7 exhibited superior characteristics such as high hardness, low friability, and rapid disintegration, aligning with the desired attributes of an orodispersible tablet. Dissolution tests indicated optimal drug release profiles, suggesting enhanced bioavailability from these formulations. The study concludes that Alverine orodispersible tablets meet the criteria for an effective orodispersible dosage form, presenting a viable alternative to conventional tablets, ensuring potential therapeutic benefits and improved patient acceptability.