Vaginal candidiasis, the second most prevalent vaginal infection, is so common that women frequently turn to herbal therapy after trying allopathic medicines. It is responsible for approximately 25% of cases, while Candida albicans is responsible for 85-95% of those cases. According to observations and reports, around 75% of females acquire vaginal candidiasis once throughout their lives, 50% twice, and 5% annually. Several plants have been found as viable remedies after reviewing the literature on herbal medicine. In the present investigation the hydroalcoholic extract of leaves of Trianthema portulacastrum Linn. were taken to formulate herbal cream. The conventional cream was formulated using extract and novel herbal cream was formulated using ethosomal suspension. The formulations were evaluated and anti-candidal activity was screened.