The current work aimed to create and analyze an emulgel based on nanosponges loaded with silver sulphadiazine for topical administration in wound healing, using the emulsion solvent diffusion method. Methods: Using ethyl cellulose, xanthan gum, and polyvinyl alcohol in various drug-polymer ratios, an emulsion solvent diffusion approach was used to create the silver sulphadiazine nanosponge. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) were used to determine the compatibility of silver sulphadiazine with polymer. Every formulation was assessed using entrapment efficiency, drug loading, scanning electron microscopy (SEM), transmission electron microscopy, zeta potential, in-vitro drug release, stability tests, and scanning electron microscopy. Results: There was no interaction between the medication and the polymer, according to the DSC and FTIR studies. Melting point of silver sulphadiazine is between 253ºC and 255ºC. It is a white powder with no smell. A straight-line curve with an R2 value of 0.9992 is produced by the calibration curve of silver sulfadiazine in a 0.5M NaOH solution. The PDI varied from 0.153 to 1.000, whereas the particle size varied from 132 to 782.4 d. nm. Value of zeta potential between -14.8 and 53.04 mV. The silver sulfadiazine DSC curve exhibits a distinct exothermic peak at 261.34ºC, signifying its microcrystalline structure. The optimal formulation's entrapment efficiency and drug content were determined to be 92.49±0.88, 91.49±0.88, 92.90, and 95.26. It was discovered that the silver sulphadiazine particles were spherical in shape and ranged in size from 10 to 60 nm. The medication was discovered to be trapped over the Silver sulphadiazine, which is represented by the structures' black sections. Following the encapsulation of the silver sulphadiazine drug inside the nanosponge, the size and form stayed the same in SEM. The method utilized to construct burn wounds consistently produced partial thickness burn lesions, according to a histological analysis of the stained samples. Conclusion: The outcomes gathered from various assessment criteria showed that the topical application of an emulgel based on silver sulphadiazine nanosponges for wound healing is a novel and successful strategy.