Background: Similar to the current public health concerns concerning the deadly Corono virus in the 2020s, polio posed a serious threat to children’s health throughout the world in the 1980s and 1990s. This article develops into the historical context of polio including its devastating impact on communities and its long standing presence in India, particularly in regions like Uttar Pradesh and Bihar. Methods: The article examines the development of Polio vaccines and concentrated efforts to combat the disease in India. Two key vaccines – oral polio vaccine and the inactivated polio vaccine played a pivotal role in polio prevention. An article highlights the critical role of these vaccines in reducing the global burden of polio cases. Results: Through the implementation of the Global Polio Eradication Initiative and India’s Pulse Polio Immunization Programme, remarkable progress was made in reducing polio cases. India’s commitment to the World Health Organization’s resolution on global polio eradication led to a substantial decline in cases, preventing countless children from suffering the debilitating effects of the disease. In 2014, the World Health Organization declared India a polio-free country after India’s extensive efforts and substantial investment. Discussion: India marked its journey to becoming a Polio-free country with dedication, innovation, and extensive community engagement. The effort included using public figures to promote immunization, launching awareness campaigns through print and radio media, and conducting intensive polio drops camps. India’s success in polio eradication was officially recognized, making it the 11th country in the Southeast Asian region to achieve polio free status.