Background: Endometriosis is one of the most common gynecological diseases, which reflects the medical and social significance of the problem of effective diagnosis and treatment. To date, the causes, diagnosis and treatment of this disease remain the subject of controversy. The pathogenesis of the disease is multifactorial and has not been sufficiently studied; non-invasive examination methods have relative diagnostic value, therefore modern therapeutic approaches often do not provide a complete cure. Purpose: Improving the diagnosis of genital endometriosis based on apoptosis markers and angiogenesis regulators. Methods: Clinical and laboratory examination of patients was carried out on the basis of the gynecological department of the perinatal center of the Bukhara Regional Perinatal Center. Patients with genital endometriosis underwent ultrasound examination of the pelvic organs, hysteroscopy, followed by targeted diagnostic curettage of the uterine cavity and histological examination of the scraping, and general clinical and laboratory research methods were used. Conclusion: Early age of manifestation of genital endometriosis is associated with genetic variants -308 AA, -308 GA tumor necrosis factor a and +36 GG, +36 AG tumor necrosis factor receptor type 1.