Nosocomial infections pose significant risks to patients in healthcare settings, leading to prolonged hospital stays, increased healthcare costs, and, in severe cases, mortality. Central Sterile Supply Department (CSSD) plays a crucial role in ensuring the cleanliness and sterility of medical instruments and equipment. This paper examines the impact of good CSSD management practices on reducing the occurrence of nosocomial infections. It reviews current literature, case studies, and best practices to highlight the importance of CSSD in infection prevention. Furthermore, the paper discusses various strategies and technologies that CSSDs can employ to enhance their efficiency and effectiveness in sterilization processes. By emphasizing the critical link between CSSD management and infection control, this paper aims to provide insights for healthcare professionals and policymakers to implement measures that mitigate the risk of nosocomial infections.