Management of hemodynamics remains one of the core tasks in perioperative and critical care settings. The basis of hemodynamic management in patients undergoing major surgery is formed by a rational titration of fluids, vasopressors and inotropes. Objective: The objective of this study was to investigate whether, the pressure regulated volume-controlled mode (PRVC) in comparison with the volume-controlled mode in patients with diastolic dysfunction, was associated with better hemodynamic alterations and different vasopressors support during anesthesia for radical cystectomy. Methods: This study was a randomized, cross-over single blinded study and included 86 adult patients of both sexes with American Society of Anesthesiologists (ASA) physical status I - II with diastolic dysfunction, the patients were randomly assigned to group 0 (VCV-PRVC) and group 1 (PRVC-VCV) in a cross-over manner according to a computer-generated randomization sequence. Hemodynamic variables included stroke volume, stroke volume variation, stroke index, cardiac output, cardiac index, systemic vascular resistance, systemic vascular resistance index (SVRI), thoracic fluid content, and corrected flow time, were measured by a Portable noninvasive cardiometry. Results: There were no statistically significant differences in demographic data such as age, sex, ASA physical status, body weight, height, body surface area (BSA), duration of surgery, anesthesia, cardiac output, and cardiac index between the two modes of ventilation. Stroke volume (SV) was significantly higher in the VCV group than in the PRVC group at the 3-hour mark from the start of the resection. Regarding fluid status parameters (SVV, FTc, and TFC), there was no statistically significant difference in stroke volume variation (SVV) or (FTc) between both modes. As regards to crystalloids, colloids, blood and plasma transfusions, blood loss, and total fluids, there were no statistically significant differences between both modes. Conclusion: no significant differences in CO, CI, SV, SVI, and SVV. Both VCV and PRVC ventilation modes could be used in patients with diastolic dysfunction undergoing major abdominal surgery, showing