Stroke is the second most common cause of death in the world, accounting for over 5.5 million fatalities each year and current treatment involves intravenous thrombolytics, fibrinogen-depleting agents, antihypertensive therapy, antidiabetic drugs, stem cell therapy, and others. Many risk factors are associated with stroke condition which includesthyroid disorder, diabetes mellitus, hypertension, obesity and age. Intravenous thrombolytic remain the main therapeutic agent in modern medicine, however several treatment approaches have been discovered to prevent and treat the stroke cascade. As herbal medicine gaining the importance in treating various diseases, they can play vital role in the maintenance of health and improvement or treatment of stroke. Numerous phytochemicals have demonstrated significant neuroprotective potential in pathogenesis of stroke through a variety of mechanisms, such as antioxidants anti-inflammation and BBB protection, mitochondrial protection and antiapoptosis. This review will discuss the source of different plants with phytochemicals and its potential clinical applications in ischemic stroke.