The current study, "Effect of Mannitol and Nano urea to mitigate the effect of terminal heat stress on wheat (Triticum aestivum L.)," was conducted during the Rabi season of 2022-2023 and 2023-2024 at the student instructional farm (SIF) of Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya-224229 (U.P.)." The experiment was conducted using the wheat variety HD 2967, three replications, seven treatments, and a split plot design. The treatment consisted of foliar spraying 25 ppm of mannitol, 50 ppm of nano urea, and 100 ppm of each at 30 DAS. Distilled water was sprayed as a control. Wheat growth, biochemistry, yield, and yield qualities have all been examined in relation to the observations. At 60, 90, and maturity stages for both timely (15 November) and late (15 December) sowing, observations were made. On the other hand, yield and yield characteristics were measured during crop harvest. Foliar spray of mannitol and nano urea were performed well at 60, 90 DAS and at maturity parameters. Foliar application of nano urea with 25 ppm was recorded superior on germination (%), Number of tiller plant-1 (cm), dry biomass plant-1 (g), Total chlorophyll content in leaves (Arnon method), Membrane injury index (%), Total soluble sugar(mg g-1 fresh weight min-1), Starch content (mg g-1 dry weight) However, yield and yield attributes viz length of spike, number of tillers plant-1, number of grains spike-1, grain yield plant-1 It is concluded from the result that foliar spray of nano urea 25 ppm was found most effective to increasing all characters and yield parameters of wheat.