Moisture stress negatively influences various morphological and biochemical processes resulting in poor growth, oxidative stress, and hampered photosynthetic activity ultimately resulting in decreased crop yield. Nanotechnology is a new strategy that can be used to address these problems. Nanoparticles when applied to crops plants, they improve the growth of plants under unfavorable conditions by activating several physiological and biochemical mechanisms. A study was carried out during the Rabi season of 2022-23 and 2023-24, using a randomized block design, with three replications and ten treatments. Wheat variety HD 2967 was used. Different combinations of nano zinc, nano titanium and calcium phosphate were used. Foliar spray was done at 45 days after sowing (DAS). ZnO (50ppm) was found most effective in increasing plant height and shoot dry biomass of the crop under conditions of moisture stress followed by ZnO (40ppm). Contrary to this, when considering antioxidant enzyme activity for SOD and catalase and also various yield attributing characters and yield ZnO (50ppm) showed a significantly higher value followed by TiO2 (40ppm)+Ca3PO4 (40ppm). The current study concludes that nanoparticles effectively reduce moisture stress in wheat particularly treatment T10 i.e., ZnO (50ppm) followed by treatment T4 i.e. TiO2 (40ppm) + Ca3PO4 (40ppm) are recommended to alleviate the negative impacts of moisture stress on wheat crops