This study explores the relationship between tacrolimus therapy and blood pressure levels in renal transplant recipients, aiming to understand the impact of tacrolimus on hypertensive outcomes and propose management strategies. Through a prospective analysis of patient data, including demographics, tacrolimus dosage, trough levels, and blood pressure measurements, the study reveals a significant incidence of hypertension among tacrolimus-treated patients. Higher tacrolimus concentrations correlate with elevated blood pressure, suggesting a dose-dependent effect. The findings emphasize the need for vigilant monitoring and tailored interventions to optimize blood pressure control in transplant recipients, potentially involving dosage adjustments, antihypertensive therapy, and lifestyle modifications. Overall, this research offers insights crucial for refining therapeutic protocols and improving clinical outcomes in renal transplant recipients.