The AIDS Pandemic signified Kaposi’s sarcoma as no longer prominent not only in African regions but also as the foremost AIDS Defining neoplasm. The Human Herpes virus-8 is the etiological agent of Kaposi’s sarcoma and is similar to Epstein Barr Virus in that replication occurs in the epithelium of the oro pharynx, with tonsils possibly acting as the major reservoir of the infection. HHV-8 detection and prevalence varies greatly depending on geographic location, ethnicity, genetic co factors and the detection method used. Kaposi’s sarcoma has been determined on histology utilizing immunohistochemistry and immunofluoresce nceassays designed to detect the latency associated molecular assays, including PCR, are highly specific for determining seropositivity. In India the clinical manifestations of HHV-8 in particular KS appears to be reduced or non-existent of serological assays-ELISA and IFA are highly dependent on assay design and antigen preparation. Serological assays to date are not highly specific or sensitive. Current advancements in serological methodologies, including immune-PCR flow conventional serological assays and permit multiplexing of antigenic targets. Research is going on determining the HHV-8 subtype and sero epidemiology in the Australian, Indian, And Kenyan HIV Positive populations to establish that will hopefully provide a much greater detection of HHV-8