Tricilisia subcordata has been used to treat a number of illnesses, so the effects of T. subcordata leaf methanol extract on hyperglycemia, hyperlipidemia, renal and hepatic abnormalities, as well as hematological indices in alloxan-induced diabetic rats, were examined. Rats were given alloxan to cause diabetic mellitus. For three weeks, the diabetic rats were given 100 mg/kg, 200 mg/kg, or 400 mg/kg of the T. subcordata extract. Weekly measurements were made of body weight and fasting blood glucose. We humbly sacrificed the rats. Analysis was done on the lipid profile, liver function, renal function, and hematological parameters. Methanol leaf extract of T. subcordata reduced weight loss and hyperglycemia in diabetic rats in a dose-dependent manner. T. subcordata lowered the elevated levels of liver enzymes and total cholesterol. The elevated creatinine levels in the serum were decreased by T. subcordata. This study shown that T. subcordata methanol leaf extract possesses hepatoprotective, renoprotective, antihyperglycemic, and antihyperlipidemic effects in alloxan- induced diabetic rats.