The objective of this research is to investigate the potential antiarthritic and anti-inflammatory effects of Dracaena trifasciata leaves using in vitro methods. The antiarthritic activity was assessed using the protein denaturation method, while the anti-inflammatory activity was evaluated using the HRBC membrane stabilization method. Results showed that the hydroalcoholic extracts exhibited significant antiarthritic effects against egg albumin denaturation with 41.56% and against standard drug Diclofenac sodium with 88.22% inhibition at 800µg/ml concentration. Leaves extract shows 53.48 % stabilization of HRBC membrane at 800 µg/ml concentration 95.64% by Diclofenac sodium at the same concentration. These findings suggest that the hydroalcoholic extract demonstrates promising potential comparable to the standard drug Diclofenac Sodium in both antiarthritic and anti-inflammatory activities, as indicated by the in vitro studies conducted using the aforementioned methods.