The growth of crystals in the urinary tract is known as urolithiasis. Mimosa pudica L. is used as a diuretic and to cure kidney stones in Ayurveda and other traditional medicine systems. The goal of the current investigation was to assess the anti-urolithiatic activity of Mimosa pudica L. extracts in rats that had been experimentally induced to develop urolithiaticbehaviour, despite the lack of scientific evidence to support this activity. Method- Sodium oxalate incited urolithiasis model in the rodent was utilized to survey the impact of oil ether remove Mimosa pudica. The examination is intended to discover the impact of concentrates of Mimosa pudica on restorative utilization against sodium oxalate incited urolithiasis. All rodents was housed in metabolic pens independently for the whole term of the investigation. The urine of each rodent was gathered on seventh day after 6 hrs of sodium oxalate infusion with Thymol as an (additive) and serum of each rodent would be gathered. Assessment of biochemical boundaries viz Urea, Uric corrosive, Creatinine, Sodium, Chlorides and Potassium in serum and urine will be finished. Helpful groups were relinquished on seventh day. Their correct kidney was inspected for the presence of calcium oxalate gems and stone development by histological procedures.