ISSN : 2663-2187

In Vitro Antioxidant And Antidiabetic Mechanistic Pharmacological Evaluation Of An Herbal Blend

Main Article Content

. Kiran Dongar Patil, D. Prerana Nandlal Jadhav, Vandana Anil Mali, Rohit N Patil
» doi: org/10.33472/AFJBS.6.7.2024.508-520

Abstract

This study investigates the antioxidant and antidiabetic properties of a herbal blend comprising of methanol cold extract of leaves of Rumex hastatus and Rumex nepalensis, two medicinal plants native to the Himalayan region. Utilizing three distinct antioxidant models—DPPH, ABTS, and FRAP assays—this research evaluated the plants' capacities to neutralize free radicals and provide protection against oxidative stress. Concurrently, their antidiabetic potentials were assessed through alpha-amylase and alpha-glucosidase inhibition assays, along with evaluating their glucose uptake activities. Results demonstrate significant antioxidant activities for the blend containing both plants, attributed to their high content of phenolic compounds and flavonoids. In antidiabetic testing, both species showed promising inhibition of key enzymes involved in carbohydrate digestion, suggesting a potential to moderate postprandial glucose levels. The dual functionality of these plants in managing oxidative stress and glucose homeostasis highlights their therapeutic potential, supporting their traditional uses and suggesting further clinical research. This study lays groundwork for future pharmacological applications and underscores the importance of these botanical resources in developing natural therapies for chronic conditions like diabetes.

Article Details