ISSN : 2663-2187

In-vitro antioxidant, in-vivo anti-inflammatory and antiarthritic activities of aqueous and ethanolic extract of leaves of Altingia excelsa species

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Madan lal kaushik1, Poonam Dogra1*, Mahendra Singh Ashawat2
ยป doi: 10.33472/AFJBS.6.5.2024.1680-1709

Abstract

With a wide range of medical uses, Altingia excelsa is intrinsic to Southeast Asia that can be found as far west as northeastern India. The antioxidant, anti-inflammatory, and antiarthritic properties of Altingia excelsa were assessed in this study, along with the amount of flavonoids and total phenolic compounds. Using 2, 2'-Diphenyl-1-picrylhydrazyl hydrate scavenging, the antioxidant activity of the extracts was determined. The carrageenan-induced paw oedema technique and the CFA-induced arithritis model were utilised to examine the anti-inflammatory and anti-arithritic capabilities in Wistar rats, respectively. For biological assessment, A. excelsa aerial parts extracts in both aqueous and ethanolic forms were utilised. The results revealed significant antioxidant activity and substantial anti-inflammatory effects in ethanolic extract as well as aqueous extract and are similiar to the standard drug Indomethacin.

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