Inflammation is the condition associated with many of the disease states and this review elaborate the medicinal plants, their parts used in the effective management of Inflammation and its associated conditions. Currently there is a greater global interest in non synthetic, natural derived from plant or herbal sources due to better tolerance and decreased adverse drug reaction. Coetaneous use of NSAIDs may result in skin rashes. Another meta-analysis concluded that even though the classical GI or renal adverse effects may be greatly reduced for topical NSAIDs. Although several agents are known to treat these types’ disorders, prolonged use should be avoided due to several side effects. Since; herbal remedies are more accepted in world for their fewer side effects and lower costs. Hence present work aimed to evaluate in-vivo anti-inflammatory activity of optimized developed polyherbal gel formulation comprising Ethanolic extract of White turmeric (Curcuma amada) Rhizome (EECA), Methanolic extract of Black pepper (Piper nigrum) fruits (MEPN) and Methanolic extract Lodhra (Symplocos racemosa) Bark (MESR), Menthol and Capsaicin. In-vivo anti-inflammatory activity polyherbal gel formulation were carried out using Carrageenan induced Paw edema in rats, Formalin induced Paw edema and Randall-Selitto Test in rats. Results showed that, polyherbal gel formulation has excellent anti-inflammatory activity as compared to marketed Diclofenac sodium gel. Hence such formulation has scope of commercial manufacturing after successful clinical trials.