The aim of this study was to evaluate the effects of fermented apple bagasse (BMF) and yeast inoculum (IL) Kluyveromyces lactis in the tilapia diet. The variables evaluated were weight gain, length, Feed Conversion Ratio (CAT) and fillet yield. Four diets were prepared, including 10% BMF (MAN Diet), 3% IL (PRB Diet) and a mixture of both (MXP Diet), compared to a control (CTL). Measurements of the fish were taken weekly and then they were slaughtered to obtain the fillet. Fish fed with BMF had a significantly higher weight at slaughter (37.93 g) than control (34.92 g), while those fed with IL were significantly lower (32.42 g) (P < 0.05). Length gain had a treatment effect (P > 0.05), with the MAN diet (92.19 mm) having a greater effect than the control diet (88.38 mm), and the PRB diet (83.84 mm) (P < 0.05). Likewise, there was a difference with respect to the ACT (P > 0.05) because the MAN Diet had a ACT of 1.78, while the control obtained 1.91. Fillet yield was higher (P > 0.05) in CTL treatments and MAN diet (52.33 and 51.15%) than MXP and PRB (44.51 and 46.4%). It is concluded that BMF acts as a source of microbial protein of good quality and high digestibility, in addition, while yeast did not present positive effects on the fish, the antioxidant compounds present in BMF provided benefits that translate into an improvement in production parameters