A two-year field study was carried out during Rabi (winter) seasons of 2021-22 and 2022-23 to find out the influence of rice residue management under different tillage and weed management options on productivity, protein yield and economics of wheat (Triticum aestivum L.) at the Agronomy Research Farm of Acharya Narendra Deva University of Agriculture & Technology, Kumarganj, Ayodhya (U.P.). The experiment was conducted with four residue management under different tillage and five weed management options in split plot design and replicated thrice. The results showed that rice residue retention with zero tillage treatments recorded highest productivity, protein yield and economics of wheat as compared to no residue treatment. While in case of different weed management options, hand weeding at 20 and 40 DAS had a significant impact in maximizing productivity, protein yield and economics of wheat closely followed by post emergence application of Clodinafop propargyl 15% + Metsulfuron methyl 1% WP PoE(60 gm + 4 gm a.i. ha-1). The highest net return and benefit: cost ratio was found in treatment combination, zero tillage with rice residue + post emergence application of Clodinafop propargyl 15% + Metsulfuron methyl 1% (60 gm + 4 gm a.i. ha-1).