Ulcers are occurs due to imbalances between aggressive factors and defensive factors. According to WHO guidelines 7.8 million people are affected every year with peptic ulcers. An available marketed drug shows side effects like arrhythmia, hypersensitivity reactions. Hence there is a need to develop safe, therapeutic, cost effective anti-ulcer drugs. Various efficient natural herbal remedies to treat ulcers but there are no scientific evaluations and explanations for those kinds of remedies. In this scenario Panicum sumatrense is one of the natural sources to boost up gastro-intestinal health status and protective agent for ulcers. The present study was designed to evaluate the antiulcer activity of Panicum sumatrense by using invivo and insilico methods. In-silico studies has done using Autodock 4.2 version with the chemical constituents of panicum sumatrense and with various proteins and we have found that gallic acid, ferulic acid have high docking score with urease protein and gastric proton pump respectively. The milk extract of Panicum sumatrense significantly decreases ulcer index when compared with methanolic extract in aspirin and pyloric ligation induced ulcer models. Significantly increases the pH and decreases the total and free acidity of gastric juice in pyloric ligation induced ulcer model. presence of ferulic acid present in panicum sumatrense which get attached with gastric proton pump. As described earlier in insilico docking scores (table no-11) ferulic acid(docking score-6.4) has binding affinity to alpha chain of gastric proton pump and has an ability to show action on it. By the above mentioned two protective measures like boosting mucus production by nourishment to gut flora and proton pump inhibiting activity, panicum sumatrense showing anti-ulcer activity by increased mucus production and decreased gastric secretions by administering methanolic and milk extracts of panicum sumatrense in dose dependent manner.