Background: Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection associated with high mortality rates. Early diagnosis using tools like the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score is crucial for timely intervention and improved outcomes. This prospective observational study aimed to evaluate the utility of the LRINEC score in predicting NF risk among patients presenting with severe soft tissue infections at Chettinad Hosipital and research institute, in department of genral surgery , kelambakkam, chennai Methods: Sixty adult patients with severe soft tissue infections were enrolled from June 2022 to May 2023. The LRINEC score was calculated based on six laboratory parameters upon admission. Patients were stratified into low, moderate, and high-risk categories. Primary outcomes included NF development confirmation, while secondary outcomes comprised hospital stay duration, follow-up visits, and surgical blood loss. Statistical analyses included descriptive statistics, ANOVA, and ROC curve analysis. Results: The LRINEC score effectively categorized patients: 20 (33.3%) as low risk (≤5), 25 (41.7%) as moderate risk (6-7), and 15 (25%) as high risk (≥8). NF incidence correlated with risk levels: 0% in low-risk, 40% in moderate-risk, and 80% in high-risk groups. Significant differences were observed in hospital stay duration (p < 0.001), follow-up visits (p < 0.001), and surgical blood loss (p < 0.001) across risk categories. The LRINEC score demonstrated a sensitivity of 80%, specificity of 88%, PPV of 80%, NPV of 100%, and AUC of 0.94 (95% CI: 0.88-0.98). Conclusion: The LRINEC score effectively stratifies NF risk in patients with severe soft tissue infections at CHRI, demonstrating high specificity and NPV. While sensitive, its clinical utility benefits from supplementary diagnostic methods and clinical judgment.