ISSN : 2663-2187

INVESTIGATION OF ANTI CANCER ACTIVITY OF PONGAMIA PINNATA AND STEVIA REBAUDIANA IN BREAST CANCER USING ANIMAL MODEL

Main Article Content

B.Dhanasree , Sajeeda Niketh , Keshamma E , Anil Kumar, M.Geetha , S.Gajendhini , Anish Banerjee , Aaryan Bhateja
ยป doi: 10.33472/AFJBS.6.5.2024. 5153-5177

Abstract

The prevalence of breast cancer is the highest among all types of cancer. The management of breast cancer involves various issues, including risk assessment and predictive diagnostics, focused prevention of metastatic disease, selection of appropriate treatment options, and ensuring cost-effectiveness of the treatments used. Extensive research has shown that phytochemicals have potential anti-cancer properties. They can keep cells from becoming cancerous, prevent the development of cancer, and hinder its spread to other parts of the body. Additionally, phytochemicals can boost the immune system and enhance the efficiency of traditional cancer treatments. The study has shown that the stevioside compound, extracted from Stevia rebudiana rebaudiana leaves, has an inhibitory effect on the growth of breast cancer cells (MDA-MB-231 and SKBR3). This compound acts by limiting cell proliferation and has potential as a targeted therapy for breast cancer. Furthermore, the findings also indicated that pure stevioside, when tested in a controlled environment, can enhance the susceptibility of breast cancer cells to 5-FU therapies. Pongamia pinnata, a native plant of the Indian subcontinent, has been extensively utilised in traditional medicine for various ailments due to its non-toxic nature and minimum or no adverse effects. This paper offers a thorough examination of the phytochemicals obtained from various components of Pongamia pinnata and the documented biological activity of the plant extracts and its constituents. Research was undertaken to discover the specific components responsible for the therapeutic function of the plant, based on traditional knowledge. This research involved extracting, isolating, and characterising the plant. Pongamia pinnata was found to possess important qualities, such as antimicrobial, antidiabetic, anti-inflammatory, and anticancer effects, when tested using in vitro and in vivo models for various disorders.

Article Details