Objective :- This study was designed to evaluate the effect of P-Cymene on Parkinson's disease (PD) induced via Rotenone in wistar albino rats. At the moment, it is thought that oxidative stress, neuron inflammation and apoptosis are plays key role in the induction of PD. Method :- For the study the animals were separated into five groups with six animals in each groups: Normal control; Toxic (Rotenone dose 1.5 mg/kg); p-Cymene + Rotenone [I]; p-Cymene + Rotenone [II]; Ropinirole + Rotenone. Daily dose of rotenone was given for 28 days. Various neurobehavioral tests including Beam crossing task (BCT), Rotarod Test, Forced swim test (FST), Morris water maze (MWM) and Catalepsy test were also performed to establish the antiparkinsonian effect of p-Cymene. After 24 hrs. of the last dosing the weights of all animals were weighed individually before sacrificing the animals after scarifying all the biochemical parameter were estimated in terms of TBARS, GSH, Catalase, and SOD in the brain tissue. Results :- On assessment of neurobehavioral test (Beam crossing task, Morris water maze, rotarod apparatus, Forced swim test, Morris water maze and Catalepsy behavioural Test) shows the activity of rotenone treated group was significantly reduced and on the treatment groups p-Cymene (25 and 50 mg/kg i.p.) it shows significant improvement in the neurobehavioural parameters. On biochemical parameters estimation results shows significant decrease in GSH, SOD, catalase and ache level in the rotenone treated rat groups which was significantly increase on the treatment groups p-Cymene (25 and 50 mg/kg i.p.). In case of TBARS estimation it shows significant increase in rotenone treated rat groups which was significantly decrease on the treatment groups p-Cymene (25 and 50 mg/kg). Conclusion :- According to the result ,it was concluded that the treatment of rotenone results in considerable oxidative stress & brain damage, while the administration of p-Cymene showed significant protective effect against PD in rats due to its robust antioxidant and positive results on neurobehavioral parameters.