The Salsola richteri plant is traditionally used for the treatment of many diseases. The objective of this study was to investigate the content of active compounds and antioxidants in three different plant parts (leaves, flowers, and roots) of Salsola richteri. Total polyphenol content (TPC) was assessed using the Folin-Ciocalteu reagent, flavonoid content (TFC) was evaluated using quercetin as a reference compound, and tannin content (TTC) was measured using tannic acid. To evaluate antioxidant properties, the assays used included 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS++ radical cation scavenging activity, iron-chelating activity, and Hydrogen Peroxide Radical Scavenging (activitywere activity). Among the extracts studied, the root extract had the highest tannin content (25.75 ± 2.08 mg AT/g DR) and the highest extraction yield (34%). The leaf extract showed the highest total polyphenol and flavonoid contents (173.98 ± 1.63 mg GAE/g DM, 135.93 ± 1.44 mg QE/g DM, respectively). The root extract also exhibited the strongest antioxidant activity, as measured by DPPH, ABTS, and FRAP assays, with lower IC50 and EC50 values indicating higher efficacy. The results indicated that all extracts demonstrated anti- hemolytic activity, with the leaf extract showing the highest inhibition rate, estimated at 93.14 ± 0.39%. Therefore, Salsola richteri extracts contain various bioactive compounds, validating their use in traditional treatments.