Alzheimer's disease (AD) is responsible for approximately 60-70% of memory loss cases. Chronic amnesia is a severe form of memory impairment that is characterized by difficulties with language, memory, and behaviour. Aging is the primary risk factor for Alzheimer's disease (AD). The incidence rate exhibits age-dependent variation. As soon as individuals attain the age of 65, the incidence rate doubles. The disease's prevalence is also differentiated by gender. The purpose of this study was to evaluate the influence of a methanolic extract of Barleria cristata leaves on memory and learning deficits in animal models. Barleria cristata is a shrub that belongs to the Acantharean flower family. The plant extract is employed for its hypoglycaemic and antispasmodic properties. Anaemia and edema are managed through the utilization of root extract. Additionally, it serves as an advantageous treatment for pneumonia, rheumatism, and snake stings.