Klebsiella pneumoniae, a member of the Enterobacteriaceae family, naturally resides in the gut microbiome of both healthy humans and animals. This pathogen is frequently found in hospitals and takes advantage of opportunities to cause infections. It is responsible for approximately one third of infections caused by Gram-negative bacteria. This study aim to identify new inhibitors of Canariumschweinfurthii that can effectively combat multidrug resistant K. pneumoniae. This was achieved through the use of molecular docking analysis. The ethanol and methanol solvents were used to extract the leaves of Canariumschweinfurthii. The results indicated that the ethanol extract exhibited a substantial inhibitory zone compared to the methanol extract. Seventeen (17) substances were found by GC-MS analysis. These compounds were subsequently filtered out using physicochemical and pharmacokinetics studies, based on Lipinski's five rule, Egan, and ADMET tool. Six (6) of the 17 compounds were found to exhibit pharmacological properties. These compounds were subjected to molecular docking with CTXM protein derived from multidrug resistant K. pneumoniae. The docking analysis results indicate that the compounds CID_143696, CID_5363192, CID_569391, CID_135403803, CID_534521, and CID_439726 have a favorable docking score. Therefore, these compounds can be regarded as potential new inhibitors for multidrug resistance in K. pneumoniae.