A massive vaccination drive is initiated so that herd immunity is developed and the population at large is prevented from the side effects of the disease. However, the success rate of vaccination is facing several challenges. A crosssectional study was carried out in rural population in central India to assess the extent of vaccine hesitancy, knowledge and attitude regarding vaccination. After consent, interviews were taken face-to-face and a structured questionnaire was administered to the participants. Of the 170 participants 158 (92.9 %) were aware about the existence of COVID-19 vaccine. 68.2% believed that vaccination is essential to stop COVID-19 pandemic whereas 49.35% were willing to get vaccinated. A greater number of males were vaccine hesitant as compared to females. The maximum hesitant participants were farm workers and had an educational qualification below 10th class. The side effects caused by the vaccine were the major concern for vaccine hesitancy (43.8%). The study shows a strong positive correlation between knowledge, attitude and vaccine acceptance indicating that proper knowledge and communication as regards to COVID-19 vaccination can be associated with a significant impact on combating the disease.