Knee pain among farmers is a prevalent and multifaceted occupational health issue that significantly impacts the well-being, productivity, and sustainability of the agricultural sector. This comprehensive analysis examines the epidemiology, risk factors, social and cultural influences, and innovative strategies for preventing and managing knee pain in farming communities. Epidemiological studies reveal varying prevalence rates of knee pain across different regions and farming practices, highlighting the global significance of this issue. Risk factors such as repetitive motion, mechanical stress, aging, environmental factors, and lack of ergonomic practices contribute to the high incidence of knee pain among farmers. Social and cultural factors, including stigma, gender dynamics, and economic constraints, further complicate the prevention and management of knee pain in this population. Innovative approaches, including technological advancements, integrated health and safety programs, educational interventions, and community engagement initiatives, offer promising avenues for addressing knee pain effectively. Collaborative efforts involving policymakers, healthcare providers, educators, community leaders, and farmers are essential for developing holistic, sustainable solutions. By prioritizing knee health and implementing targeted interventions, we can enhance the quality of life for farmers, ensure the longevity of agricultural livelihoods, and foster a resilient and thriving farming community.