Background:Background: Proper knowledge about risk factors and prevention of congenital malformations in pregnant women can lead to primary prevention of disease.Aim of the study was to assess knowledge of pregnant women about fetal congenital anomalies.Subjects and Method:Research design: A descriptive design. Setting: The study was conducted at maternity outpatient clinics at Zagazig university hospitals in Sharkia Governorate, Egypt. Subjects: Purposive sample of 574 pregnant women who attended the selected setting. Tools of data collection: Two tools were used for data collection. Tool 1: interviewing questionnaireand Tool 2: knowledge questionnaire about fetal congenital anomalies. Results: Theoverall knowledge of pregnant women about fetal congenital anomalies showed that there were highly statistically significant differences between total knowledge of the studied women and their gravidity, parity and history of stillbirth at (p <0.001). While, there was no statistically significant differences with women’scurrent gestational age, history of abortion, antenatal follow up, history of delivery of child with congenital anomalies, family history of congenital anomalies and complications of current pregnancy at (p > 0.05). Conclusion: More than two thirds (69.2%) of the studied sample had unsatisfactory level of total knowledge about fetal congenital anomalies. While, (30.8%) of them had satisfactory level of total knowledge about fetal congenital anomalies. Recommendation: There is a need for public programs to increase knowledge about congenital anomalies in pregnant women and people