Background: Resin based dental materials like composites and pit and fissure sealants have been used progressively for preventive and restorative purposes in pediatric dentistry. Nevertheless, the harmful systemic implications of these Bisphenol A (BPA) derivatives haven’t been paid heed to. Owing to the growing apprehension with regard to the compounds that leach from resin based materials, it is very important to estimate the amount of monomers that leach out them. Other than being an endocrine disruptor, BPA is hypothesized to exert oxidative stress and cause an imbalance between the number of oxidants and antioxidants i.e. the Total Antioxidant Capacity (TAC). As the usage of BPA based dental materials is a growing public concern, as dentists it is critical to understand whether the use of BPA products pose a genuine exposure risk. Objective: This study aims to observe the levels of BPA and total anti-oxidantcapacity (TAC) in saliva after placement of resin based pit and fissure sealants in children. Methodology: 40 healthy children in the age group of 6 to 9 years were selected for the study and divided into two groups of 20 each by random sampling. Unstimulated saliva was collected before placement, immediately and 24 hours after placement of resin based sealants (Group A)and glass ionomer sealants (Group B). Concentration of BPA and TAC level in saliva were compared between the two groups using Enzyme Linked Immuno-Sorbent Assay (ELISA) and photospectrometry respectively. Results: Baseline BPA (ng/ml) concentrations in saliva were comparable in both Group A (0.39 ± 0.10) and Group B (0.40±0.11). However, exponentially higher BPA levels were seen immediately after placement of sealants (19.51±2.30) in Group A, when compared to Group B (0.42± 0.12). The mean BPA level decreased significantly after 24 hours of placement in Group A (1.42±0.39), although it was still significantly higher than Group B (0.43±0.14) and the baseline values for both the groups. The Baseline TAC (mM/l) levels in saliva were comparable in both, Group A (0.39±0.07) and Group B (0.38±0.05). A slight alteration was seen in the TAC levels immediately and 24 hours after placement, in both the Group A (0.40±0.08), (0.41±0.06) and Group B (0.39±0.06), (0.40±0.07). However, there was no significant difference in the TAC values before placement, after and 24 hours after placement in both the groups. Conclusion: Sources other than resin based materials contribute a baseline level of BPA in saliva. An exponential rise in the salivary BPA level was seen immediately after placement of resin based sealants. However, this level significantly dropped in 24 hours. In case of glass ionomer sealants, no change was seen immediately and 24 hours after the sealant placement. The TAC levels before, immediately and 24 hours after placement of resin and glass ionomer based sealants remained statistically insignificant.