Background: Chronic kidney disease (CKD) is characterized by decline in kidney function. The normal kidney function is lost in patients having chronic renal insufficiency; the most affected are the excretory and regulatory functions, as a result of infections, autoimmune conditions, diabetes, hypertension, cancer, or exposure to poisonous chemicals. One of the most prevalent side effects of chronic renal failure (CRF) is dyslipidemia, which is often associated with declining renal function and is evident even in early stages of CRF. AIM: The study aimed to compare and correlate the pattern of low-density lipoprotein (LDL) and triglycerides (TG) in patients having CKD. Methods: This case-control study was carried out at Integral Institute of Medical Sciences Lucknow on 100 patients with CKD in age group 18 to 75 years and divided in 2 groups (cases with CKD of stage-I to II (GFR of >60 ml /min/1.73m2) and case group included 50 cases with CKD of stage-IIIA-V (GFR <60 ml/min/1.73m2) on hemodialysis. Patients if who had Coronary Artery Disease, Heart Failure, fever, pyrexia of unknown origin (PUO), acute Poisoning, HIV positive patient, viral infection, skin infection, parasitic infestation, patients on anti-inflammatory drugs, any known malignancy were excluded. Result: The age in the majority of them fell between 18 and 75 years, and the gender distribution was insignificantly distributed. Serum urea, serum creatinine, triglycerides and LDL was significantly higher (p<0.05) in case group than in control group. Estimated glomerular filtration rate (eGFR) of case group was lower than in control group and was found statistically significant (p<0.05). Age, Serum Urea, Serum Creatinine, Triglyceride and LDL has a negative correlation with the eGFR. Conclusion: An increase in triglycerides and LDL levels are important risk factors for the development of CKD based on eGFR. Sustained monitoring and cautious interpretation of the triglycerides and LDL in CKD patients will be needed in clinical practice