The Himalayan region is one of the major biological hot spot in the world rich in medicinal and aromatic plants (MAPs). Polygonatum cirrhifolium (Wall) Royle is an herbaceous medicinal plant found in the Himalayan region. P. cirrhifolium (Wall) Royle; locally known as Mahameda, belongs to a group of eight medicinal plants known as “Astavarga”. Whole plants and especially rhizomes and seeds are rich in important bioactives like triterpenoid saponin, steroidal saponins, flavonoids, and phytosterols owing to its immense medicinal properties. These bioactive have been reported in treating various diseases such as bronchitis, TB, leprosy, urogenital edema, cough, worms, menstrual irregularities, etc. P. cirrhifolium (Wall.) Royle is classified as an endangered medicinal plant species, due to habitat fragmentation, poor seed germination, high anthropogenic pressure for trade, and unscientific collection from the wild. Both in-situ and ex-situ conservation measures are needed for maintaining its natural populations. P. cirrhifolium (Wall.) Royle might be explored to discover other therapeutic components by means of isolating noble compounds, characterization of those components, and their organic assessment. It can also be suggested that the population of endangered plants with superior medicinal value can be used for conservation prioritization and management planning of these species. Among all “Astavarga” plants, P. cirrhifolium (Wall.) Royle is the least explored scientifically. Therefore, this current review article mainly focuses on the geological distribution along with the medicinal properties of P. cirrhifolium and their therapeutic uses.