Purpose:To evaluate the Yttrium-oxide partially stabilized zirconia (Y-TZP) to Bio HPP 3-unit fixed dental prosthesis (FDP) frameworks in terms of marginal adaption and fractureresistance. Methods: Using a standardized 3-unit FDPs framework, two groups (n = 10/group) were created, Group 1: Zirconia (Z) and Group 2: Bio HPP(B). Using a USB digital microscope with built-in camera connected to an IBM compatible personal computer (50 X) and each specimen was photographed before cementation and after thermodynamic aging to establish marginal adaptability.After thermodynamic aging, fracture resistance was measuredusing Universal Testing machine. Compressive static force was applied at thecenter of pontic'socclusal surface, with a cross-head speed of 1 mm/min. The load required for fracture was recorded in Newton. Results: 3-way ANOVA followed by pair-wise Tukey post-hoc test indicates statistically non-significant difference in marginal gap mean value (P=0.0825>0.05) between Zirconia(24.31±3.1μm) and Bio HPP (23.27 ±2.13μm). Regardless the type of material and abutment, with a p-value of <0.0001>0.05, the mean gap size after aging(30.88 ±3.3 μm)was found to be statistically significantly higher than before cementation. Student t-test (t=2.3, p=0.003<0.05) revealed that Bio HPP had a statistically significant (p<0.05) greater fracture resistance mean value (1828.41±181.41N) than Zirconia (1441.23±165.3N). Conclusions: In contrary to zirconia, Bio HPP FDP showed non-significantly greater marginal adaptation; still, Bio HPP outperformed zirconia in terms of fracture resistance. Marginal adaptability of thermo-mechanical aging was significantly lower in all frameworks examined, although it was still within a clinically acceptable range.